Correlation of Vaccine Responses

Impact of the Gut Microbiota on Vaccine Responses

Non-responsiveness or poor responsiveness to vaccines are challenging issues in vaccine development, and efforts have been made to find out the potential reasons for these conditions. Intestinal microbiome plays a key role in regulating and development of immune system and the composition and diversity of microbiota in different individuals on the one hand, and the imbalance of intestinal micro...

Understanding Poor Vaccine Responses: Transcriptomics of Vaccine Failure

Immunosenescence is a functional and phenotypic exhaustion observed in adaptive and innate immune cell subsets, leading to an increased rate of infection, decreased vaccine responsiveness, and autoimmunity (Aw, Silva, & Palmer, 2007). Immunosenescence occurs with advancing chronological age and in individuals with a chronic viral infection. These changes ultimately result in increased mortality...

Correlation with Biochemical Responses

X 1010 sites/100 ,ug protein, and the other with an apparent Kd of 25 nM and a binding capacity of 1.4 X 1012 sites/100 ,g protein. Measurement of the ability of several thyronine analogues to inhibit the binding of [1251I]T3 revealed the following rank order of potency: L-T3 > L-T4 > D-T3 = D-T4 > L-3,5-T2 > rT3 > D,Lth*ronine. Binding of T3 was inhibited by the omission of calcium from the me...

Serological Responses of Horses Immunized with Live Attenuated African Horse Sickness Vaccine

Stool microbiota and vaccine responses of infants.

OBJECTIVE Oral vaccine efficacy is low in less-developed countries, perhaps due to intestinal dysbiosis. This study determined if stool microbiota composition predicted infant oral and parenteral vaccine responses. METHODS The stool microbiota of 48 Bangladeshi infants was characterized at 6, 11, and 15 weeks of age by amplification and sequencing of the 16S ribosomal RNA gene V4 region and b...